Simmons R, et al. - In order to assess the causes of death among hepatitis C virus (HCV) infected persons in England, researchers linked persons ≥1 year with anti-HCV/HCV-PCR tests reported to PHE sentinel surveillance during 2002-2016 to death registrations from the Office for National Statistics during 2008-2016. Evidence of HCV was identified in 204,265 cases; of these, 8.6% died during the study period. Among them, the leading underlying causes of death were external causes (accidental poisoning from drugs) and liver disease (end-stage liver disease, liver cancer, hepatitis, alcohol- and non–alcohol-related), 18% and 34.5%, respectively. These patients had a lower median age of death than the general population (53 years vs 81 years). Persons with HCV died of external causes, liver disease, and HIV, in a higher proportion when compared to the general population. New HCV treatments were noted inducing a relative reduction in liver-related deaths in 2016 compared with 2015. This study supports the efficacy of data linkage between laboratory diagnosis and deaths data as a tool to monitor all-cause mortality among those with HCV and quantify under-reporting of HCV in death registrations. In people with HCV, changes in mortality trends (causes and prematurity) can help in assessing the impact of HCV treatment scale-up and other interventions to achieve HCV elimination in the UK.