Mathew S, et al. - Given the beneficial impact endocardial and epicardial ablation of ventricular tachycardia (VT) may have on arrhythmogenic right ventricular cardiomyopathy/dysplasia, researchers assessed a sequential approach for VT ablation in these patients in a single center. They examined 47 patients (44±16 years) with definite (81%) or borderline (19%) arrhythmogenic right ventricular cardiomyopathy/dysplasia who had ablation (the strategy was to target the endocardial substrate). Those who faced acute ablation failure or in cases with a lack of an endocardial substrate, the adopted strategy was epicardial ablation. This analysis included 81 radiofrequency ablation procedures. A total of 65 (80%) procedures were completely successful; 13 (16%) were partially successful. Freedom from the primary end point (sustained VT/ventricular fibrillation, heart transplant, and death after the index procedure, and sustained VT/ventricular fibrillation for multiple procedures) was seen in 17 (36%) patients after a median 50.8 months of follow-up. A substantial number of arrhythmogenic right ventricular cardiomyopathy/dysplasia patients with VT could be effectively treated with endocardial ablation, potentially preventing the need for an epicardial approach.