Bruneto EG, Fernandes-Silva MM, Toledo-Cornell C, et al. - Given the emergence of orally-transmitted acute Chagas disease (CD) as an important public health problem, researchers sought to report on its prognosis via analyzing and summarizing data on orally-transmitted acute CD. From government sources that reported patients with acute CD orally-transmitted, they identified 41 relevant papers published from 1968 to January 31, 2018, and added 932 unpublished cases. In total, 2,470 cases and occurrence of 97 deaths were reported in this study. Per estimates from meta-analysis, the case-fatality rate was 1.0%. Findings here suggest considerable lethality related with orally-transmitted acute CD in the first year after infection. Similar lethality was reported in symptomatic cases to that from other routes of infection. Over the years, a decline has occurred in the lethality rate of orally-acquired disease.