Hageman SHJ, de Borst GJ, Dorresteijn JAN, et al. - Among participants of the Utrecht Cardiovascular Cohort - Secondary Manifestations of ARTerial disease (1996–2017) study, with symptomatic vascular disease, researchers examined the association between non-high-density lipoprotein cholesterol (non-HDL-c), systolic blood pressure (SBP) and smoking and the risk of major adverse limb events (MALE) and the combination with major adverse cardiovascular events (MALE/MACE). Experts identified no link between non-HDL-c and MALE among patients with peripheral artery disease (PAD), and the risk of MALE was found to be higher per 1 mmol/L non-HDL-c among patients experiencing coronary artery disease (CAD), cerebrovascular disease (CVD) or abdominal aortic aneurysm (AAA). Per 10 mm Hg SBP, patients with PAD and those with CVD/CAD/AAA demonstrated a higher risk of MALE. A higher risk of MALE was observed in smokers with PAD and CAD/CVD/AAA. Overall, findings revealed disparity in the risk of MALE and MALE/MACE based on vascular disease location in patients with symptomatic vascular disease. In these patients, the risk of MALE and MALE/MACE was found to be related to non-HDL-c, SBP and smoking. MALE was corroborated as significant as an outcome, and risk factor management is important among patients with vascular disease.