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Cardiovascular mortality among patients with non-Hodgkin lymphoma: Differences according to lymphoma subtype

Hematological Oncology Mar 30, 2019

Abuamsha H, et al. - Researchers used the US Surveillance, Epidemiology, and End Results (SEER) database to determine the burden of cardiovascular mortality (CVM) among patients ≥20 years of age diagnosed with diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). They used multivariable Cox regression analysis to determine the link between non-Hodgkin lymphoma (NHL) and CVM, after adjustment for other patient characteristics. Deaths of 9,017 patients (5.8%) due to cardiovascular disease were reported. A higher risk of CVM was found among NHL patients vs the general population, after adjusting for age. Patients with DLBCL, CLL/SLL, and FL demonstrated 5.1%, 8%, and 4.4% rates of CVM, respectively. Factors related to higher risks of CVM across all NHL subtypes included older age, higher stage at the time of diagnosis (particularly stage IV), male sex, and living in the South. NHL patients, especially those with the CLL/SLL subtypes, should undergo risk assessment and careful cardiac monitoring.

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