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Cardiovascular medication use and long-term outcomes of First Nations and non–First Nations patients following diagnostic angiography: A retrospective cohort study

Journal of the American Heart Association Aug 21, 2019

Dahl L, Schultz A, McGibbon E, et al. - Given a greater mortality risk exists among First Nations (FN) people in Canada vs the general population after index angiography, and this difference has not been examined while considering guideline-suggested cardiovascular medication use, so, researchers performed a retrospective analysis of administrative health data to analyze patterns of medication dispensation during the first year following index angiography among patients in Manitoba, Canada. For β-blockers, angiotensin-converting enzyme inhibitors, statins, and antiplatelets (clopidogrel), they separately calculated medication possession ratios (MPRs) indicating the percentage of days in which medications were provided. Among patients with known ischemic heart disease, an independent association of FN status with intermediate and high MPRs for statins was reported during the first year after index angiography. The 2 populations showed differences in all-cause and cardiovascular mortality, which could not be explained by disparities in MPR categories. In order to address the reduction of cardiovascular differences, in the best manner, the use of primary prevention strategies that involve decolonizing policies and practices was suggested.
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