Scotti A, Godino C, Munafò A, et al. - Since there is lack of clarity about the role of the target vessel in percutaneous revascularization of chronic total occlusion (CTO), researchers herein investigated the long‐term outcomes of percutaneous coronary intervention (PCI) for CTO lesions in each coronary artery, as well as inquired about the influence of successful revascularization and prior myocardial infarction (MI) in the territory of the target vessel. In this cohort observational study, they included 1,124 patients who have received CTO PCI attempt: 371 on left anterior descending artery, 485 right coronary artery, and 268 left circumflex. Infarct‐related artery (IRA) was defined as vessels affected by a previous MI. Findings demonstrated lower cardiac survival as well as freedom from sudden cardiac‐death/sustained ventricular‐arrhythmias in relation to unsuccessful percutaneous CTO revascularization, regardless of the vessel treated. This finding was primarily driven by patients with an IRA CTO.