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Burden of dengue infection in India, 2017: A cross-sectional population based serosurvey

The Lancet Global Health Jul 17, 2019

Murhekar MV, et al. - Through a community-based survey in 240 clusters (118 rural, 122 urban), chosen from 60 districts of 15 Indian states from five geographical regions of 17, 930 individuals from June 19, 2017, to April 12, 2018, the researchers measured the age-specific seroprevalence, the force of infection, and the number of infections in India. In the southern, western, and northern regions, the seroprevalence was observed as high. The overall seroprevalence of dengue virus (DENV, most rapidly spreading vector-borne disease worldwide) infection in India was 48·7%, rising from 28·3% among children aged 5–8 years to 41·0% among children aged 9–17 years and 56·2% among people aged between 18–45 years. The estimated number of primary DENV infections with the constant force of infection model was 12,991,357 and 8,655,425 for the age-dependent force of infection model among people aged 5–45 years from 30 Indian states in 2017. Hence, in the northern, western, and southern regions, the burden of dengue infection in India was concluded as heterogeneous, with proof of high transmission. Moreover, the survey findings would be beneficial in making knowledgeable decisions regarding the introduction of upcoming dengue vaccines in India.
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