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Body mass index in young women and risk of cardiomyopathy: A long-term follow-up study in Sweden

Circulation Feb 25, 2020

Robertson J, Lindgren M, Schaufelberger M, et al. - By performing this registry-based national prospective cohort analysis, researchers investigated if for young women being overweight or obese is related to a higher risk of encountering cardiomyopathy. They used the Swedish Medical Birth Register to obtain data for women who were of childbearing age (18–45 years) during the initial antenatal appointment in their first or second pregnancy. The final sample included 1,388,571 women. During a follow-up of 33 years, 1,699 cases of cardiomyopathy were reported, with an incidence rate of 5.9 per 100,000 observation years. Findings revealed that high BMI in young women was related to a raised risk of being diagnosed with subsequent cardiomyopathy, particularly dilated cardiomyopathy, beginning already at mildly raised body weight, whereas severe obesity caused an approximately 5-fold rise in risk. As the numbers of individuals who are overweight or obese are rising, higher rates of cardiomyopathy can be anticipated in the future, along with a modified disease burden associated with adiposity.
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