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Bloodstream infections caused by Klebsiella pneumoniae: Prevalence of blaKPC, virulence factors and their impacts on clinical outcome

BMC Infectious Diseases Aug 06, 2018

Xu M, et al. - In Klebsiella pneumoniae isolated from patients with bloodstream infections (BSIs), researchers examined the prevalence of blaKPC (K. pneumoniae carbapenemase) and virulence factors. They also sought for their association with clinical outcome. Retrospective evaluation of clinical data of 285 K. pneumoniae BSI cases diagnosed from January 2013 to December 2015 in a Chinese university hospital was performed. Findings reveal that to antibiotics, most of hypermucoviscous K. pneumoniae (HMKP) are susceptible, and infected people got the appropriate antimicrobial treatment, which may explain the favorable outcome of HMKP BSIs. The KPC-producing HMKP BSIs occur rarely but are life-threatening. blaKPC had value for forecasting 14-day mortality.

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