de Havenon A, Fino NF, Johnson B, et al. - Researchers, for the first time, explored the connection between increased blood pressure variability (BPV) and recurrent ischemic stroke. They performed a secondary analysis of 17,916 individuals in the PRoFESS (Prevention Regimen for Effectively Avoiding Second Strokes) trial, the largest trial of patients with potential recurrent stroke. They calculated BPV and assessed its impact on recurrent stroke (composite and stratified by ischemic or hemorrhagic stroke), major cardiovascular events (death from cardiovascular causes, recurrent stroke, myocardial infarction, or new or worsening heart failure), and all-cause death. Findings suggested an association of systolic and diastolic BPV with recurrent stroke, major cardiovascular events, and all-cause death. For ischemic, but not hemorrhagic, stroke association was significant. Data reported that the hazard ratio for a recurrent ischemic stroke was 1.15, for major cardiovascular events was 1.19, and for all-cause death was 1.24 for every 10-point increase in BPV. Future work should concentrate on assessing whether BPV actively reduces the risk of cardiovascular disease by using widely available and inexpensive antihypertensive drugs.