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Blood pressure thresholds and neurologic outcomes after endovascular therapy for acute ischemic stroke: An analysis of individual patient data from 3 randomized clinical trials

JAMA Feb 05, 2020

Rasmussen M, Schönenberger S, Henden PL, et al. - In order to find out whether procedural blood pressure parameters, including specific blood pressure thresholds, are associated with neurologic outcomes after EVT, researchers conducted a retrospective cohort study recruiting adults with anterior-circulation AIS who were enrolled in randomized clinical trials assessing anesthetic strategy for EVT between February 2014 and February 2017. A total of 365 individuals enrolled in the analysis. The outcomes of this study showed that critical MABP thresholds and durations for poor outcomes were determined to be MABP less than 70 mm Hg for more than 10 minutes and MABP greater than 90 mm Hg for more than 45 minutes, both durations with a number required to harm of 10 individuals. After EVT, it was indicated that mean arterial blood pressure may be a modifiable therapeutic target to prevent or reduce poor functional outcome.
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