Mistry EA, Sucharew H, Mistry AM, et al. - In this prospective, multicenter, cohort study with a prespecified analysis plan involving 485 patients (median age, 69 [interquartile range, 57–79] years), researchers identified the specific postendovascular stroke therapy (EVT) peak systolic blood pressure (SBP) threshold that best discriminates good from bad functional outcomes (a priori hypothesized to be 160 mm Hg). At 12 comprehensive stroke centers accross the US from November 2017 to July 2018, consecutive adult patients treated with EVT for an anterior ischemic stroke were registered. In order to best distinguish good from bad functional outcome, a peak post-EVT SBP of 158 mm Hg has been prospectively identified. Those with a peak SBP > 158 were more likely to have a bad result in unadjusted, but not in adjusted study. The effect size found was similar to previous research. In a future randomized trial of goal-targeted post-EVT antihypertensive treatment, this finding should be further tested.