Massera D, et al. - The association of osteocalcin (OC), a marker of bone formation, and C-telopeptide of type I collagen (CTX), a marker of bone resorption, with incident diabetes in older women was investigated via analyzing data of 1,455 female participants from the population-based Cardiovascular Health Study. Using multiple linear regression, the cross-sectional association of serum total OC and CTX levels with insulin resistance (HOMA-IR) was investigated. It was observed that lower OC and CTX levels were correlated with similarly increased risks of insulin resistance at baseline and incident diabetes over long-term follow-up in late postmenopausal women.