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Baseline white blood cell count-to-apolipoprotein A1 ratio as a novel predictor of long-term adverse outcomes in patients who underwent percutaneous coronary intervention: A retrospective cohort study

Lipids in Health and Disease Mar 20, 2020

Pan Y, Zhang J, Wu TT, et al. - In this study with 5,678 patients with coronary heart disease (CAD) who underwent percutaneous coronary intervention (PCI), researchers determined how baseline white blood cell count-to-apolipoprotein A1 level (WAR) influences long-term outcomes post-PCI. Three groups of patients were defined based on WAR value: lower group - WAR < 5.25 (n = 1,889); median group - 5.25 ≤ WAR ≤ 7.15 (n = 1,892); and higher group - WAR ≥ 7.15 (n = 1,897). The comparisons between patients in the higher group and those in the lower group, in multivariate Cox regression analyses, revealed a rise of 62.6%, 45.5%, 21.2%, and 23.8% in the risk of all-cause mortality (ACM), cardiac mortality (CM), major adverse cardiovascular and cerebrovascular events (MACCEs), and major adverse cardiovascular events (MACEs), respectively. Patients with a WAR ≥ 4.635 vs those with WAR < 4.635 were found to have 92.3, 81.3, 58.1 and 58.2% increased risks of ACM, CM, MACCEs and MACEs, respectively. At 10-year follow-up, every 1 unit rise in WAR was found to be related to 3.4, 3.2, 2.0 and 2.2% increased risks of ACM, CM, MACCEs and MACEs, respectively. Overall, baseline WAR was identified as a new and an independent predictor of adverse long-term consequences in CAD patients who received PCI.

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