Allen CJ, Joseph J, Patterson T, et al. - Researchers reassessed the association between baseline NT‐proBNP (N‐terminal pro‐brain natriuretic peptide) and symptomatic improvement post-TAVI (transcatheter aortic valve implantation). A total of 144 consecutive patients receiving TAVI for severe symptomatic aortic stenosis were reviewed regarding symptom status, clinical and echocardiographic data, and baseline NT‐proBNP. A nonlinear, inverted‐U link was identified between log‐baseline NT‐proBNP and post‐TAVI alteration in NYHA class. Findings demonstrated not only the usefulness of baseline NT‐proBNP as a prognostic marker to predict poor symptom relief post-TAVI but also indicated that it may serve as an indicator for the likely futility of the intervention. A strong association of both low (<800 ng/L) and very high (>10 000 ng/L) levels with poor functional outcome was identified, indicating an alternative reason for symptoms in the former scenario and an irrevocably diseased left ventricle in the latter.