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Associations of perfluoroalkyl and polyfluoroalkyl substances with incident diabetes and microvascular disease

Diabetes Care Jul 19, 2019

Cardenas A, et al. - Via analyzing data from a prospective cohort of 957 candidates from the Diabetes Prevention Program (DPP) trial and Outcomes Study (DPPOS), researchers explored if perfluoroalkyl and polyfluoroalkyl substances (PFASs) correlated with diabetes incidence and microvascular disease and if a lifestyle intervention alters connections and lowers concentrations. Participants were 957 participants from the Diabetes Prevention Program (DPP) trial and Outcomes Study (DPPOS). Investigators found that each doubling of N-ethyl-perfluorooctane sulfonamido acetic acid correlated with 17% higher odds of prevalent microvascular disease; a comparable relationship with perfluorodimethylhexane sulfonic acid was observed, irrespective of treatment. The authors concluded that some plasma PFASs were linked to diabetes and microvascular disease. The findings indicate that exercise and diet may diminish the connection of PFASs with diabetes.

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