Bidulescu A, Dinh PC, Sarwary S, et al. - Via involving candidates (n = 3,363; mean age 53 years) from the Jackson Heart Study, researchers evaluated the correlation of leptin and adiponectin with incident type 2 diabetes (T2D), their interactions with gender and obesity status, and mediation by insulin resistance. Data reported that 584 developed incident T2D in this analysis. According to findings, leptin's association with incident T2D has been mediated by insulin resistance among African Americans in the Jackson Heart Study. This correlation was only present among participants who were abdominally non-obese. Gender differences appeared: men displayed a significant correlation mediated by insulin resistance. Even after adjustment for HOMA-IR, adiponectin was inversely linked to incident T2D among abdominally obese candidates. The findings will inform future clinical trials aimed at reducing the burden of T2D by adjusting the serum leptin and adiponectin levels.