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Associations of cytokine concentrations in aqueous humour with retinal vascular abnormalities and exudation in Coats’ disease

Acta Ophthalmologica Nov 15, 2018

Zhang J, et al. - In patients with Coats’ disease, authors gauged the correlations of cytokine concentrations in aqueous humour with the severity of retinal vascular abnormalities, exudation, and fibrosis. Findings suggested the probability of angiogenin to act as a potential biomarker for retinal vascular abnormalities in Coats’ disease. They noted a positive correlation of the concentrations of vascular endothelial growth factor (VEGF) and monocyte chemoattractant protein-1 (MCP-1) with the severity of retinal exudation. In eyes with retinal fibrosis, the aqueous humour transforming growth factor-β (TGFβ) concentrations were higher than in non-fibrotic eyes with Coats’ disease.
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