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Associations between measures of sarcopenic obesity and risk of cardiovascular disease and mortality: A cohort study and Mendelian randomization analysis using the UK Biobank

Journal of the American Heart Association Jun 27, 2019

Farmer RE, et al. - Given the “healthy obese” premise, suggesting those with higher muscle quality (mass/strength) see a reduction in the risks related to extra adiposity, researchers investigated the correlation between sarcopenia, obesity, and their interaction with cardiovascular disease events and mortality in this cohort study of 450,000 UK adults. Adiposity was determined using baseline body mass index; muscle quality was assessed using handgrip strength (HGS). As per outcomes, higher body mass index was associated with higher cardiovascular and all-cause mortality risk and people with better muscle quality showed no attenuation of this association. Outcomes thereby provide no support to the “healthy obese” concept. Observational and Mendelian randomization analyses revealed the correlation of lower HGS with greater risks of mortality, indicating the possibility of reverse causality being not the sole explanation.

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