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Associations between calcium and magnesium intake and the risk of incident gastric cancer: A prospective cohort analysis of the NIH-AARP Diet and Health Study

International Journal of Cancer Sep 06, 2019

Shah SC, Dai Q, Zhu X, et al. - Using Cox proportional hazard modeling, researchers estimated the risk of incident gastric adenocarcinoma (GA) overall and by anatomic location, noncardia (NCGA) and cardia (CGA), in correlation with dietary and supplemental intakes of calcium and magnesium. This analysis involved 536,403 respondents (59% males, 41% females). Among these, the occurrence of 1,518 incident GAs (797 NCGA, 721 CGA) was reported. Findings revealed a link of increasing calcium consumption with a lower risk of GA overall, driven principally by the link with NCGA, where above median calcium intakes were found to be related to a 23% attenuation in risk vs the lowest quartile. Non-white races and Hispanics, current/former smokers, obese individuals, and those with high NCGA risk scores were found to have a greater magnitude of this NCGA risk reduction. Only males demonstrated 22–27% reduced risk of NCGA in correlation with increasing magnesium consumption, while for the cohort, a 34% attenuated risk of NCGA was reported in correlation with dietary magnesium consumption in the highest vs lowest quartile.
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