Arnold SV, et al. - In this analysis of a large, registry-based US cohort, health status outcomes after transcatheter edge-to-edge mitral valve repair (TMVR) in routine clinical practice as well as factors related to improvement were assessed. The KCCQ (Kansas City Cardiomyopathy Questionnaire) data available in 81.2% at baseline, 69.3% of survivors at 30 days, and 47.4% of survivors at 1 year, was analyzed. Prior to the procedure, impaired health status was reported, which showed improvement within 30 days, and continued to be stable through 1 year among surviving patients with available data. The factors that were independently related to lower 30-day KCCQ-Overall Summary scores (OS scores) were atrial fibrillation, permanent pacemaker, severe lung disease, home oxygen, and lower KCCQ scores at baseline, as revealed in multivariable analysis. A high long-term mortality was reported, nevertheless, improvements were evident in symptoms, functional status, and quality of life in most surviving patients, with only modest differences by patient-level factors.