Sato K, et al. - Researchers examined the diagnostic utility of measuring the catheter-based time between left ventricular (LV) and aortic systolic pressure peaks (T_LV-A_o) in patients with severe aortic stenosis (AS). They conducted a cohort study of 123 patients with severe AS at the Cleveland Clinic Foundation, a tertiary referral center, who underwent transcatheter aortic valve replacement (TAVR) via femoral access and had pre-TAVR cardiac computed tomography assessment and hemodynamic measurements recorded during a TAVR procedure. Outcomes revealed independent association of greater T_LV-A_o with higher aortic valve (AV) calcification. In addition, greater T_LV-A_o had an incremental value in identifying patients with significant AV calcification vs conventional echocardiographic variables. In a subgroup of patients with low-gradient AS, only T_LV-A_o was noted to be associated with AV calcification, while other echocardiographic parameters showed no correlation to AV calcification. These findings support T_LV-A_o as a new index to grade AS severity. Further, it may act as a valuable surrogate to differentiate low-gradient true severe AS among patients undergoing TAVR.