Luvián-Morales J, et al. - In this retrospective cohort study, researchers examined the association of the prognostic nutritional index (PNI) and other well-known prognostic factors with overall survival (OS) by multivariate analysis in a cohort of patients (n=3301) with colorectal cancer (CRC) (mean age was 58.7 years, 47.7% were female). A strong relation of PNI with OS was shown in bivariate analysis. The components of the final prognostic model were: PNI, location of the neoplasia in the colorectum, basal hemoglobin, lymphocyte count, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, TNM stage, differentiation degree, R classification, and postoperative complications. In CRC patients, PNI was identified as a significant and independent prognostic factor. The TNM staging system, including specific subgroups of patients with CRC, was more precise when PNI was taken into account.