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Association of structural and functional cardiac changes with transcatheter aortic valve replacement outcomes in patients with aortic stenosis

JAMA Cardiology Mar 27, 2019

Fukui M, et al. - In this cohort study of 689 consecutive patients with severe aortic stenosis who had a transcatheter aortic valve replacement (TAVR), researchers intended to corroborate the reproducibility of a recently proposed staging system for aortic stenosis that estimates the degree of structural and functional cardiac alterations in aortic stenosis. Via a survival analysis, they also intended to extend the study findings. They focused on the link between aortic stenosis staging and both cardiac and noncardiac post–TAVR readmissions. This study did not include patients who had undergone TAVR for valve-in-valve procedures and had baseline echocardiogram findings that were incomplete or unavailable for review. As per the findings of this study, a strong graded link between the extent of cardiac changes and all-cause mortality following TAVR was demonstrated by aortic stenosis staging. With the help of such staging, patient care, risk stratification, prognosis evaluation, and shared decision making could be improved for patients undergoing TAVR.
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