Association of retinal biomarkers and choroidal vascularity index on optical coherence tomography using binarization method in retinitis pigmentosa
Graefe's Archive for Clinical and Experimental Ophthalmology Nov 22, 2019
Cetin EN, et al. - In this prospective study involving 36 patients (69 eyes) with retinitis pigmentosa (RP), researchers explored the correlation of retinal biomarkers with the choroidal parameters in RP. According to results, having DRIL and the disruption of ellipsoid zone (EZ) and external limiting membrane (ELM) was significantly linked to higher choroidal vascularity index (CVI), defined as the ratio of luminal area to stromal area after binarization on EDI–OCT images, and lower peripapillary choroidal thickness (CT) in the temporal sector. Having ERM, the disruption of EZ and ELM was significantly related to lower visual acuity (VA). Findings suggested a significant association of the disruption outer retinal segment integrity with higher CVI and lower peripapillary CT in temporal segment. ERM and disruption of ELM and EZ have been linked to worse VA. There was no significant correlation between VA and CT, peripapillary CT, or CVI.
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