Zhang X, Wang A, Zhang J, et al. - Experts aspired to explore if genetically raised plasma C-reactive protein (CRP) concentration levels were correlated with ischaemic stroke (IS) on the basis of the Mendelian randomization method. In 378 first-ever IS patients and 613 healthy controls, four CRP-associated SNP alleles (rs1130864, rs1205, rs876537 and rs3093059) with minor allele frequency ≥ 0.15 were chosen and the concentration levels of CRP were estimated. The OR of IS for plasma CRP ≥ 2.0 mg/l was 2.19 vs < 2.0 mg/l. According to this Mendelian randomization study, there was no clear support that elevated CRP concentration was causally related to the risk of IS.