O’Leary JM, Clavel MA, Chen S, et al. - This cohort study is done to examine the links of elevated B-type natriuretic peptide (BNP) levels following transcatheter aortic valve replacement (TAVR) and alteration in BNP levels between follow-up time points with risk of subsequent clinical results. Participants were patients experiencing severe symptomatic aortic stenosis at intermediate, high, or prohibitive surgical risk for aortic valve replacement who were managed with TAVR. Following adjustment, a raised hazard of all-cause mortality, cardiovascular mortality, and rehospitalization between 30 days and 2 years was noted in correlation with every 1-point rise in BNP ratio at 30 days (nearly equivalent to a rise of 100 pg/mL in BNP). Lower risk of subsequent events was observed in relation to reductions in BNP levels during follow-up. Overall, findings revealed an independent correlation between elevated BNP levels post-TAVR and increased subsequent mortality and rehospitalizations.