Dorsheimer L, et al. - In this cohort study, researchers evaluated the potential prognostic significance of clonal hematopoiesis of indeterminate potential (CHIP) in 200 patients with chronic heart failure (CHF) due to ischemic origin. Bone marrow–derived mononuclear cells from these patients (median age 65 years) were analyzed. In 38 of 200 patients with CHF (18.5%), 47 mutations with a variant allele fraction (VAF) of at least 0.02 were found. Subjects who were older and more frequently had a history of hypertension were found to have CHIP. A median follow-up of 4.4 years revealed death in 53 patients and that 23 patients required hospitalization for heart failure. Findings suggested a possible significant correlation of somatic mutations in hematopoietic cells, especially in the most commonly mutated CHIP driver genes TET2 and DNMT3A, with the progression and poor prognosis (increase in death and rehospitalization for heart failure) of CHF.