Patel RB, et al. - Since there is a lack of clarity regarding the longitudinal patterns of alteration in urine albumin-to-creatinine ratio (UACR) through young adulthood as well as their links with myocardial structure and function later in life, therefore, researchers analyzed the trajectory of albuminuria as determined by UACR across a 20-year span, as well as assessed the link of albuminuria trajectory with echocardiographic indices of structure and function in middle age in the CARDIA study. This analysis included 2,647 individuals with mean (SD) age 35.2 (3.6) years, 1,441 (54.4%) were white, 1,206 (45.6%) were black. Experts discovered 5 trajectory groups of UACR, including 1,718 participants (64.9%), 682 (25.8%), 116 (4.4%), 88 (3.3%), and 43 (1.6%) in the low-stable group, moderate-stable group, high-stable group, moderate-increasing group, and in the high-increasing group, respectively. Aside from the high-increasing cohort, median baseline UACR levels less than 30 mg/g were identified in the rest of the 4 groups. Findings revealed different patterns of the shift in albuminuria among young adults over a 20-year duration, and baseline UACR level alone was not sufficient to enable the recognition of these trajectory groups. An independent link was identified between dynamic shifts in albuminuria and adverse changes to cardiac structure, left ventricular (LV) systolic function, and LV diastolic function.