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Association of longitudinal trajectory of albuminuria in young adulthood with myocardial structure and function in later life: Coronary Artery Risk Development in Young Adults (CARDIA) Study

JAMA Nov 26, 2019

Patel RB, et al. - In this cohort study involving 2,647 black and white young adults, researchers outlined the trajectory of albuminuria as measured by urine albumin-to-creatinine ratio (UACR) across a 20-year span and assessed the correlation of albuminuria trajectory with echocardiographic indices of structure and function in middle age. Findings suggested that 5 distinct trajectory groups of UACR were identified, which could not be identified by baseline UACR levels alone. In the moderate-increasing and high-increasing UACR groups, male sex, current smoking, diabetes, and elevated blood pressure were more common. Findings suggested an independent association of UACR trajectory group with long-term adverse alterations to the cardiac structure, left ventricular systolic function and left ventricular diastolic function. Young adults over a 20-year period have distinct patterns of albuminuria transition, and these trajectory groups can not be defined by baseline UACR level alone.
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