Gu X, Li Y, Chen S, et al. - By analyzing six cohort studies in China involving 267,500 participants, researchers examined the link of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C ), high-density lipoprotein cholesterol (HDL-C), and triglyceride with stroke. Via Cox proportional hazards regression models and restricted cubic spline analyses, they estimated hazard ratios and 95% CIs as well as investigated linear and nonlinear links of lipids and stroke, respectively. The participants were observed for a median duration ranging from 6 to 19 years. The development of stroke was reported in 8,072 individuals during 2,295,881 person-years. Findings revealed positive links of TC, LDL-C, and triglyceride with ischemic stroke. In the presence of TC lower than 120 mg/dL, a higher risk of hemorrhagic stroke was observed. There was no link of LDL-C and triglyceride with hemorrhagic stroke. Higher risks of ischemic and hemorrhagic stroke might be reported in the presence of HDL-C lower than 50 mg/dL.