Gdowski MA, Murthy Vl, Doering M, et al. - A systematic review and meta‐analysis of observational studies were conducted to ascertain the correlation of coronary microvascular dysfunction (CMD) with outcomes. Researchers carried out to search online databases for studies where coronary flow reserve was assessed invasively or noninvasively, clinical events were noted after determination of coronary flow reserve, and the frequency of those events was recorded for patients with and without CMD. All‐cause mortality was the primary endpoint. Major adverse cardiac events, including cardiac or cardiovascular death, nonfatal myocardial infarction, cardiac hospitalization, or coronary revascularization were considered as secondary endpoints. The findings revealed that CMD is correlated with a nearly 4‐fold elevate in mortality and a 5‐fold increase in major adverse cardiac events. Further research is required to distinguish effective strategies to diagnose and treat CMD.