Tröbs SO, Prochaska JH, Schwuchow-Thonke S, et al. - Researchers undertook this observational, prospective MyoVasc cohort study to determine the factors related to global longitudinal strain (GLS) as well as its prognostic worth in patients suffering from chronic heart failure (HF). A total of 3,289 people with asymptomatic to symptomatic HF were enrolled, and participants were observed for a median span of 3.2 years (interquartile range, 2.0-4.0 years). By multivariable regression analysis, the following factors were independently related to GLS: age, female gender, obesity, atrial fibrillation, myocardial infarction, and estimated glomerular filtration rate. In this study population of chronic HF cases, GLS was found to be related to clinical and cardiac status, reflected neurohormonal activation, and was shown to be related to cardiac mortality independent of clinical and cardiac status. Based on findings, experts inferred that GLS may afford a beneficial instrument to enhance risk stratification in patients suffering from HF.