Murai N, Saito N, Kodama E, et al. - This investigation examined the relationship between ghrelin dynamics and beta-cell function. Participants in the study were 1,145 healthy people < 40 years old who tested normal on the 75-g oral glucose tolerance tests (OGTT). The following indicators and the ghrelin suppression ratio were calculated during OGTT: insulin sensitivity (SI) [1/homeostasis model assessment of insulin resistance, insulin sensitivity index-Matsuda, and 1/fasting insulin (1/FIRI)]; and β [Stumvoll first-phase index (Stumvoll-1), Stumvoll second-phase index, and insulinogenic index]. In non-obese individuals, Stumvoll-1 and 1/FIRI exhibited a hyperbolic connection and the Stumvoll-1 and 1/FIRI product was used as the disposition index. In individuals with normal glucose tolerance, ghrelin dynamics were linked to beta-cell function. Glucose intolerance in obesity may be caused not only by resistance to insulin but also by the impaired beta-cell function associated with ghrelin dynamic abnormalities.