Lotta LA, et al. - In genetic studies with up to 636,607 people, researchers identified genetic variants linked with higher waist-to-hip ratio (WHR), specifically lower gluteofemoral or higher abdominal fat distribution, and projected their link with cardiometabolic risk. The hip- and waist-specific polygenic scores for higher WHR were related to lower gluteofemoral and higher abdominal fat in dual-energy x-ray absorptiometry analyses. Results of this study suggested that specific genetic mechanisms might be linked to gluteofemoral and abdominal fat distribution used to calculate the WHR. These findings can improve diabetes and coronary disease risk assessment and treatment.