Melgarejo JD, Yang WY, Thijs L, et al. - Given that major adverse cardiovascular events are closely related to 24-hour blood pressure (BP), therefore, researchers investigated outcome-driven thresholds for 24-hour mean arterial pressure (MAP). They used a population-based cohort (n = 11,596) to examine the link of major adverse cardiovascular events with 24-hour MAP, systolic BP (SBP), and diastolic BP (DBP). The 10-year major adverse cardiovascular events risks yielded by 24-hour MAP levels of < 90 (normotension, n = 6,183), 90 to < 92 (elevated MAP, n = 909), 92 to < 96 (stage-1 hypertension, n = 1,544), and ≥ 96 (stage-2 hypertension, n = 2,960) mm Hg were equivalent to those yielded by office MAP categorized by 2017 American thresholds for office SBP and DBP. On top of 24-hour MAP, higher 24-hour SBP raised, whereas higher 24-hour DBP reduced risk. Based on the findings, experts inferred that refined risk estimates can be obtained by clinical application of 24-hour MAP thresholds in conjunction with SBP and DBP.