Chen HY, Cairns BJ, Small AM, et al. - Researchers undertook this genome-wide association study with a case-control design to determine new genetic loci and pathways related to aortic stenosis (AS). This analysis involved 44,703 participants (3,469 cases of AS) of self-reported European ancestry who were selected from the Genetic Epidemiology Research on Adult Health and Aging cohort. For performing replication, 7 other cohorts with 256 ,926 participants (5,926 cases of AS) were used. A total of 6,942 participants from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium were selected to perform additional analyses. Experts found a higher ratio of arachidonic acid to linoleic acid was related to aortic valve calcium (AVC). In mendelian randomization, the link of increased FADS1 liver expression as well as of arachidonic acid with AS was revealed. Overall, variation at the FADS1/2 (fatty acid desaturase) locus was found to be related to AS and AVC. The results from biomarker measurements and mendelian randomization seemed to link ω-6 fatty acid biosynthesis to AS, which may be a treatment target.