Frye MA, Coombes BJ, McElroy SL, et al. - Researchers undertook this case-control study to find out if there exists a difference in antibodies to common infectious agents, including cytomegalovirus (CMV), Toxoplasma gondii, and measles, as well as in inflammatory marker C-reactive protein in serum samples of patients with bipolar disorder vs people without bipolar disorder (controls). Participants were 1,207 patients with bipolar disorder and 745 controls, the serum samples of whom were collected from biobanks with participating sites in Rochester and Minneapolis, Minnesota (n = 1,537), and Cincinnati, Ohio (n = 415). Findings revealed the association of increased long-term antibody response to CMV and reduced long-term antibody response to T gondii, with bipolar disorder and the subphenotypes of bipolar type I, nonearly disease onset, and manic psychosis.