Bagur R, et al. - In this international, multicenter study, researchers investigated the impact of comorbidity on the clinical outcomes after transcatheter aortic valve implantation (TAVI). For this purpose, they examined 1,887 patients from the United Kingdom, Canada, Spain, Switzerland, and Italy; data were collected between 2007 and 2016. They used a two-stage individual participant data (IPD) random effect meta-analysis to study the association of Charlson Comorbidity Index (CCI) with 30-day mortality, Valve Academic Research Consortium-2 (VARC-2) composite early safety, long-term survival, and length of stay by using logistic regression and Cox proportional hazard models. The analysis was performed as a whole cohort and at a country level. They observed a significant comorbid burden in patients undergoing TAVI. The CCI and well-established preoperative risks scores were found to be weakly correlated to each other. Following TAVI, a moderate link was observed between CCI and long-term mortality up to 5 years.