Bagur R, et al. - Researchers performed this multicenter international study to determine the association of the Charlson Comorbidity Index (CCI) with clinical outcomes following transcatheter aortic valve implantation (TAVI). They analyzed data collected between 2007 and 2016 from 1,887 patients from the UK, Canada, Spain, Switzerland and Italy and used logistic regression and Cox proportional hazard models to calculate the association of CCI with clinical outcomes. Significant a comorbid burden was observed in patients undergoing TAVI. The CCI and well-established preoperative risks scores weakly correlated with each other. A moderate association of CCI with long-term mortality was reported up to 5 years after TAVI.