Zhang Y, et al. - Via this meta-analysis of nine studies with 810 hepatocellular carcinoma (HCC) and 172 cirrhosis patients, researchers examined the link between caveolin-1 (CAV-1) protein expression and HCC. They used Review Manager 5.2. They also calculated pooled ORs and HR with corresponding CIs. Findings revealed a correlation of CAV-1 protein overexpression with the risk of cirrhosis; with an OR of 3.25. In HCC with cirrhosis vs HCC without cirrhosis, a significantly higher rate of CAV-1 protein overexpression was found, indicating CAV-1 protein overexpression as a possible trigger for carcinogenesis in liver with cirrhosis as well as its subsequent contribution to the progression of HCC. A strong correlation of CAV-1 protein overexpression with poor overall survival was evident in patients with HCC; with an HR of 0.4. The risk for liver cirrhosis and HCC derived from cirrhosis was present in cases with CAV-1 protein overexpression. Also, CAV-1 was identified as a promising prognostic predictor in HCC.