Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China
JAMA Apr 01, 2020
Shi S, Qin M, Shen B, et al. - By performing this cohort investigation in a single center at Renmin Hospital of Wuhan University, Wuhan, China, from January 20, 2020, to February 10, 2020, researchers examined the link between cardiac injury and mortality among patients with coronavirus disease 2019 (COVID-19). The follow-up was performed until February 15, 2020. Overall 416 hospitalized cases with COVID-19 were analyzed. Cardiac injury was present in 82 patients (19.7%). These patients, vs those without cardiac injury, were found to be older; experienced more comorbidities; were found to have higher leukocyte counts and levels of C-reactive protein, procalcitonin, creatinine kinase–myocardial band, myohemoglobin, high-sensitivity troponin I, N-terminal pro-B-type natriuretic peptide, aspartate aminotransferase, and creatinine; and had a higher proportion of multiple mottling and ground-glass opacity in radiographic findings. The proportions of cases needing noninvasive mechanical ventilation or invasive mechanical ventilation were greater among patients with cardiac injury vs those without cardiac injury. Those with vs without cardiac injury more frequently encountered complications, such as acute respiratory distress syndrome, acute kidney injury, electrolyte disturbances, hypoproteinemia, and coagulation disorders. Overall, in this patient population, cardiac injury was common and was found to be related to higher risk of in-hospital mortality.
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