Kabore EG, Guenancia G, Vaz-Luis I, et al. - Researchers sought to examine the correlation of BMI and cardiotoxicity (defined as a reduction in left ventricular ejection fraction [LVEF] > 10 percentage points from baseline to LVEF < 50%) by using prospective data collected between 2012 and 2014 in the French national multicenter prospective cancer toxicities study of 26 French cancer centers. In this study, the enrolled a sum of 929 individuals with stage I–III breast cancer (BC). They examined the relationships between BMI and cardiotoxicity using multivariate logistic regression. Nearly 50% of the study population was overweight or obese at baseline. Compared to the normal-weight group, the obese group was more prone to cardiotoxicity. Obesity and administration of trastuzumab were independently correlated with cardiotoxicity in multivariate analysis. They found that obesity appears to be correlated with an important increase in risk-related cardiotoxicity in BC individuals.