Association of African ancestry with electrocardiographic voltage and concentric left ventricular hypertrophy: The Dallas Heart Study
JAMA Cardiology Dec 24, 2018
Alame AJ, et al. - Researchers investigated if the proportion of genetically determined African ancestry among self-reported black individuals was related to increased electrocardiographic voltage and concentric left ventricular (LV) hypertrophy [(LVH)] in 2,077 participants from the Dallas Heart Study which included English- or Spanish-speaking Dallas County, Texas, residents, with deliberate oversampling of black individuals. Those aged 18 to 65 years who enrolled in the Dallas Heart Study between July 2000 and December 2002, self-identified as black (n = 1251) or white (n = 826), and had electrocardiography (ECG), cardiac magnetic resonance imaging (CMR), and dual-energy radiography absorptiometry (DEXA) data were examined. Findings revealed an association between genetically inferred proportion of African ancestry and increased electrocardiographic voltage and measures of concentric LV hypertrophy as assessed by cardiac magnetic resonance imaging, this was seen in multivariable models adjusting for age, sex, blood pressure, antihypertensive medication use, and body composition. In analyses restricted to black individuals only, the persistence of these links was evident.
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