Mori H, et al. - In 166 patients with type 2 diabetes (aged ≥30 years), researchers assessed how sarcopenia (age-related decrease in the strength of skeletal muscle accompanied with the loss of muscular mass) and dynapenia correlates with accumulated advanced glycation end-products (AGEs), a major cause of diabetic vascular complications. For this investigation, skin autofluorescence (as a marker of AGEs), limb skeletal muscle mass index, grip strength, knee extension strength, and gait speed were evaluated. In 7.2 and 13.9% of participants, sarcopenia and dynapenia, respectively, were noted. In patients with sarcopenia and dynapenia, skin autofluorescence was significantly higher. The independent determinant of skeletal muscle mass index, grip strength, knee expansion strength, sarcopenia, and dynapenia was skin autofluorescence. In patients with type 2 diabetes, accumulated AGEs could lead to decreased muscle mass and strength, resulting in sarcopenia and dynapenia.