Bae EH, Lim SY, Han KD, et al. - Researchers used data from the Korean National Health Insurance System and examined the link between blood pressure (BP) variability and the risk of end-stage renal disease (ESRD). Participants were observed over a median duration of 7.89 ± 0.88 years. Overall 16,567 cases of ESRD were reported during follow-up. A higher incident rate of ESRD was observed in the highest quartile of systolic or diastolic BP vs the other 3 quartiles. The highest incidence rate of ESRD was exhibited by the uncontrolled hypertension group (> 140/90 mm Hg) receiving antihypertensive medication, among patients with the highest quartile of systolic and diastolic BP variabilities. Overall, findings revealed the independent association of systolic and diastolic BP variabilities with a raised incidence of ESRD, and the combined presence of both variabilities was associated with its augmentation.