Garzillo CL, et al. - Via a cohort study using 10-year follow-up data from the Medicine, Angioplasty, or Surgery Study II randomized clinical trial with 270 participants, researchers evaluated whether documented stress testing–induced myocardial ischemia correlated with major adverse cardiovascular events or ventricular function changes in patients with stable multivessel coronary artery disease (CAD). A total of 535 out of 611 underwent exercise stress testing at baseline, ie, 270 with documented ischemia and 265 without. Between the presence of ischemia at baseline and survival free of combined cardiovascular events, no correlation was observed following multivariable adjustment that involved CAD initial randomized treatments. Moreover, the small decline in left ventricular ejection fraction following 10 years was comparable in both groups, among 320 subjects who underwent echocardiographic assessment. The presence of documented myocardial ischemia did not seem to be related to a higher occurrence of major adverse cardiovascular events or variations in ventricular function in those with multivessel CAD over long-term follow-up, despite the therapeutic strategy applied.