Garzillo CL, Hueb W, Gersh B, et al. - In this cohort study using 10-year follow-up data from the Medicine, Angioplasty, or Surgery Study II randomized clinical trial, researchers evaluated whether documented stress testing–induced myocardial ischemia was related to major adverse cardiovascular events or ventricular function variations in individuals with stable multivessel coronary artery disease (CAD). A total of 535 of 611 individuals underwent exercise stress testing at baseline ie, 270 with documented ischemia and 265 without. Following multivariable adjustment that involved CAD initial randomized treatments, no correlation was discovered between the presence of ischemia at baseline and survival free of combined cardiovascular incidents. Moreover, among 320 individuals who underwent echocardiographic assessment, the small drop in left ventricular ejection fraction following 10 years was comparable among both groups. Hence, in this study, in individuals with multivessel CAD during a long-term follow-up, irrespective of the therapeutic approach used, the presence of documented myocardial ischemia did not seem to be related to an elevated occurrence of major adverse cardiovascular events or variations in ventricular function.