Qian F, et al. - A total of nine studies comprising 307,099 individuals with 23,544 cases of incident T2DM, were recognized in order to quantitatively integrate accessible prospective observational evidence on the relationship between plant-based dietary patterns and risk of T2DM. With modest heterogeneity across studies, a notable inverse relationship was noted, in comparison with poorer adherence, between higher adherence to a plant-based dietary pattern and risk of T2DM. When using the fixed-effects model, comparable findings were noted. Across predefined subgroups, steady correlations were seen. When healthy plant-based foods, like fruits, vegetables, whole grains, legumes, and nuts, were involved in the definition of plant-based patterns, the relationship was established. In terms of dietary evaluation, disease outcomes, and statistical adjustment for confounding factors, most studies were considered to have superior quality. Via restricted cubic splines, a meaningful inverse linear dose-response correlation between plant-based dietary indices and risk of T2DM was recognized. Hence, for the primary prevention of T2DM, plant-based dietary patterns, particularly when they are supplemented with healthy plant-based foods, could be advantageous.